| Date | Location | Result | |
| Oct 08, 2021 | Kearney, NE | Nebraska-Kearney 35, Missouri Western 14 | Box score |
| Sep 09, 2021 | St. Joseph, Mo. | Missouri Western 38, Fort Hays State 31 | Box score |
| Oct 02, 2021 | St. Joseph, Missouri | Northwest Mo. St. 30, Missouri Western 7 | Box score |
| Nov 13, 2021 | Jefferson City, Miss | Missouri Western 41, Lincoln (MO) 12 | Box score |
| Nov 06, 2021 | St. Joseph, Missouri | Missouri Western 59, Central Mo. 28 | Box score |
| Oct 30, 2021 | Joplin, Missouri | Missouri Western 45, Mo. Southern St. 28 | Box score |
| Oct 23, 2021 | St. Joseph, Missouri | Pittsburg St. 34, Missouri Western 14 | Box score |
| Oct 16, 2021 | St. Joseph, | Missouri Western 57, Northeastern St. 24 | Box score |
| Sep 25, 2021 | Topeka, Kansas | Washburn 47, Missouri Western 41 | Box score |
| Sep 18, 2021 | St. Joseph, Missouri | Missouri Western 38, Emporia St. 37 | Box score |
| Sep 02, 2021 | Edmond, | Central Okla. 24, Missouri Western 20 | Box score |